|
|
|
Case 2:
History:
2 year old female goat, presented with intermittent scouring, weight loss,
lethargy and inappetence.
Severely thickened mucosa – sections of ileum.
Mucosa has a “corrugated” appearance with transverse folds, but is smooth and glistening.
Small Intestine (x400). Lamina propria – heavily
infiltrated by large epithelioid macrophages (arrowheads)
Slide Ref: 1104/90 *
Small Intestine (x400). ZN stain: intracellular acid
fast (red) organisms within macrophages
Slide Ref: 1104/90 *
Small Intestine (x1000). Acid fast bacteria within macrophages
– lamina propria
Slide Ref: 1104/90 *
Johnes Disease:
Mycobacterium paratuberculosis = intracellular organism,
and induces a severe, chronic granulomatous enterocolitis, lymphangitis
and lymphadenitis in ruminants. Results in malabsorption and increased
permeability (exudation) with protein losing enteropathy, diarrhoea and hypoproteinaemia which produces anasarca.
|
