Veterinary Pathology - Cell Degeneration

Introduction

Histological Findings:

Haematoxylin & Eosin (x400)

At low power, a distinct change can be seen between the normal hepatocellular architecture and a region of cells that contain large vacuoles consistent with lipid. The fatty change within the hepatocytes is uniform across all the acinar zones.

The sharp demarcation, the uniformity of the lesion and its close proximity to a capsular adhesion all suggest that physical forces exerted locally to this liver area may have resulted in these changes.

Take a moment to piece together the information presented and examine the photomicrographs carefully and see if you can determine how the abnormalities identified may all be linked.

Cases

Carbontetrachloride

Review Questions