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Tension Lipidosis:
This is a case of tension lipidosis. The small adhesion
to the hepatic capsule had placed constant tension on the capsule, resulting
in reduced blood flow to all the hepatocytes within the affected zone.
Relative hypoxia of these hepatocytes in turn caused reduction in the
rate of ATP dependent metabolism. As synthesis of proteins for export
of lipid (as lipoproteins) out of hepatocytes is an energy-consuming process,
triglyceride fats accumulated within the compromised cells .
The damage to the hepatocytes is potentially reversible
if the tension on the capsule is relieved.
Fatty change is histologically distinctive and relatively
easy to identify in H&E-stained tissue sections. However, an oil-red
O stain or Sudan black stain could be used on frozen tissue sections to
confirm the presence of lipid.
 
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Veterinary
Pathology - Cell Degeneration