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Single Cell Necrosis:
This form of necrosis may appear histologically similar
to apoptosis, but it is not a recognised preprogrammed cell death and
there is not the ordered process of cell autodestruction and packaging
for easy phagocytosis.
Single cell necrosis often occurs in areas of pathological
over crowding of cells, inflammtion, toxic cell injury and within neoplasms.
However, increasingly the death of neoplastic cells in tumours is recognized
to be due to the process of apoptosis.
Haematoxylin & Eosin (x400)
In this section of liver a small number of cells can be
seen which are hyper-eosinophilic and contain pyknotic nuclei. There
is also a mild inflammatory response evident with increased numbers of
Kupffer cells (hepatic macrophages) within the regionand sequestered
neutrophils. This appearance is most consistent with single cell necrosis.
 
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Veterinary
Pathology - Necrosis