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Fibrinoid Necrosis:
The development of fibrinoid necrosis is dependent on
the presence of large quantities of antigen-antibody complexes and thus
is either an autoimmune response or reflective of a chronic viral or bacterial
infection. The arthritic changes are similar in development to the vascular
lesions with the deposition of immune complexes and another favoured site
of deposition is the glomerulus of the kidney.
Ancillary tests
Confirmation of fibrin as the pink material accumulating
in place of vascular walls can be obtained by positive staining using
what technique?
Identification of immune complexes requires specific
immunological staining of the tissues.
 
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Veterinary
Pathology - Necrosis