Introduction

Skin Incision - day 16:

Haematoxylin & Eosin (x40)

The immature connective tissue (IC) within the dermis continues to mature and as it does the prominent vascular channels of the granulation tissue begin to regress and the tissue becomes paler (blanching). Over months this process continues until the immature fibrous tissue matures to a point that it is almost indistinguishable from the original dermal connective tissue, except that lost structures such as hair follicles are never replaced.

Haematoxylin & Eosin (x400)

Fibrous scar (FS) in between mature dermal collagen (DC). The number of nuclei visible within the fibrous scar is much less than in granulation tissue (compare with previous images). This is due to fibrous contraction and atrophy/apoptosis of endothelium, macrophages and fibroblasts.

Primary Intention

Second Intention

Granulation Tissue

Review Questions

Back to Prac Classes