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Mass:
Small, multiple nucleoli are visible. There is very little
variation in nuclear shape and size. Mitotic figures were present (arrowhead) (x1000)
Schwannoma:
Schwannomas are derived from Schwann cells, and are centred
on and may envelop peripheral nerves. Tumours can be benign or malignant
(malignant schwannomas).
Grossly, these tumours form a locally infiltrative mass but even poorly
differentiated malignant variants do not metastasise. Schwannomas may
cause pain and neurological deficits.
Histologically, the elongated spindle cells are arranged in whorls, repetitive
palisades and often herring-bone weaves. Malignant variants may contain
metaplastic bone or cartilage. Some schwannomas may be melanin-pigmented.
The presence of atypical mitoses and a low to moderate mitotic rate
would classify this type of tumour as malignant.
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