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Secondary Wound:
2, 3 and 4 weeks following biopsy.
Haematoxylin & Eosin (x40)
A thin band of epithelium covers the area and the scab
has fallen off. However a large area of granulation tissue can be seen
beneath the surface(G). Contraction of myofibroblasts will gradually reduce
the size of this region and greatly decrease the size of the resulting
scar. Note wound contraction can only occur in regions of skin that are
mobile and not stretched (ie usually the body trunk, not the legs and
head where the skin is more tightly adherent to bones etc).
Trichrome Stain (x40)
The stain highlights the newly produced immature fibrous
tissue which is laid down within the region of granulation tissue. Compare
this volume of granulation tissue with that of a wound healing by primary
intention.
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